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Acetonitrile is a commonly used polar aprotic solvent
May 07, 2018

 
     In inorganic chemistry, acetonitrile is widely used as a ligand and its abbreviation is MeCN. For example, the acetonitrile complex PdCl2(MeCN)2 can be prepared by heating a suspension of polymerized palladium chloride in acetonitrile. Due to its higher dielectric constant, acetonitrile is a popular cyclic voltammogram solvent. Acetonitrile is also a two-carbon raw material for organic synthesis. It reacts with cyanogen chloride to give malononitrile. Acetonitrile also serves as a mobile phase separation molecule and is often used for column chromatography and more modern high performance liquid chromatography.
     In the nuclear medicine field, acetonitrile is used to synthesize positron-based radioactive drugs such as fluorodeoxyglucose. In the process of synthesizing FDG, the evaporation of acetonitrile can take away the water in the reaction system. The amount of acetonitrile in the reaction system plays a decisive role in the synthesis efficiency and drug quality of FDG. At the same time, acetonitrile also serves as a matrix for solvents and reaction systems. In addition, acetonitrile water mixture is also used in the routine quality inspection of FDG. For example: 85% v/v as the mobile phase for thin layer chromatography.