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Acetonitrile laboratory use
May 07, 2018

 
    Acetonitrile, also known as methyl nitrile, is a colored liquid that is particularly volatile and has an ether-like odor. It also has good solvent properties and can dissolve many organic and inorganic substances. It can be made into vitamin A, carbon amine drugs and so on.
    Acetonitrile Laboratory Uses: Acetonitrile is a commonly used polar aprotic solvent. In inorganic chemistry, acetonitrile is widely used as a ligand and its abbreviation is MeCN. For example, the acetonitrile complex PdCl2(MeCN)2 can be prepared by heating a suspension of polymerized palladium chloride in acetonitrile. Due to its higher dielectric constant, acetonitrile is a popular cyclic voltammogram solvent. Acetonitrile is also a two-carbon raw material for organic synthesis. It reacts with cyanogen chloride to give malononitrile. Acetonitrile also serves as a mobile phase separation molecule and is often used for column chromatography and more modern high performance liquid chromatography. In the nuclear medicine field, acetonitrile is used to synthesize positron-based radioactive drugs such as fluorodeoxyglucose. During the synthesis of FDG, the evaporation of acetonitrile can remove the water in the reaction system; the amount of acetonitrile in the reaction system has a decisive influence on the synthesis efficiency and drug quality of FDG; at the same time, acetonitrile acts as a solvent and reaction. The matrix of the system. In addition, in the routine quality inspection of FDG, acetonitrile:water mixture (for example, 85%?v/v) is also used as the mobile phase for thin layer chromatography analysis.