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Tert-butyl acetate production process
Mar 27, 2018

1.Acetyl anhydride method: Tert-butyl alcohol, acetic anhydride and anhydrous zinc chloride are mixed and heated to reflux for 2 h, then cooled, distilled to a temperature of 110° C., the crude oil is washed with water, and washed with 10% potassium carbonate to neutrality. , Drying with anhydrous potassium carbonate, and then distillation, collecting 95-96 ° C distillate derived products.
2. Acetyl chloride method Mix tert-butanol, N,N-dimethylaniline and anhydrous ether, heat reflux, add acetyl chloride, control feed temperature, maintain moderate reflux speed, add 2/3 acetyl chloride, N The crystals of N-dimethylaniline hydrochloride were cooled in an ice bath and then heated for 1 h. Water was added to dissolve all the solids, the ether layer was separated, extracted with cold 10% sulfuric acid, washed with saturated sodium bicarbonate solution once, dried over anhydrous sodium sulfate, and fractionally distilled to obtain a finished product.
3. Acetyl chloride-magnesium method Mix magnesium powder, tert-butanol and anhydrous ether, add acetyl chloride and anhydrous ether solution, add cooling, add cold potassium carbonate solution to decompose, extract 3 times with ether. Calcium chloride drying, distillation derived products.